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KMID : 0882420180930050439
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Korean Journal of Medicine
2018 Volume.93 No. 5 p.439 ~ p.446
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Antimicrobial Therapy for Infections Caused by Carbapenem-Resistant Gram-Negative Bacteria
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Wi Yu-Mi
Kang Cheol-In
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Abstract
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Carbapenem-resistance emerging in Gram-negative pathogens, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, has become a major human health problem globally. The therapeutic options available for carbapenem-resistant pathogens are very limited. Antibiotics such as colistin, tigecycline, fosfomycin, and aminoglycosides are often the only ones that can be used to treat carbapenem-resistant pathogens. Carbapenem may still be an option in certain circumstances. The administration of combination therapy for carbapenem-resistant pathogens is controversial. This review presents the current knowledge of available antimicrobial therapeutic options for infections due to carbapenem-resistant pathogens in Korea.
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KEYWORD
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Gram-negative bacteria, Carbapenem, Drug resistance, Treatment outcome
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